Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.36 |
| ▸ | HTR2C | P28335 | 11/20 | 0.36 |
| ▸ | HTR2B | P41595 | 9/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10840512 | 0.86 | HTR2C (0.45) | HTR2AHTR2CHTR2BARPGR | |
| SCHEMBL23846923 | 0.80 | OPRL1 (0.32) | OPRL1NISCH | |
| SCHEMBL28387436 | 0.76 | OPRL1 (0.32) | OPRL1 | |
| SCHEMBL26503987 | 0.76 | PDE9A (0.33) | HTR2AHTR2CAR | |
| SCHEMBL19656991 | 0.72 | HTR2C (0.45) | HTR2AHTR2CHTR2BHTR1ASLC6A2 | |
| SCHEMBL23846917 | 0.72 | — | — | |
| SCHEMBL19656756 | 0.69 | HTR2C (0.46) | HTR2AHTR2CARPGR | |
| SCHEMBL10840664 | 0.69 | NOTUM (0.42) | HTR2AHTR2CHTR2BHTR1ASLC6A2 | |
| SCHEMBL10840667 | 0.68 | AR (0.43) | HTR2AHTR2CHTR2BARPGR | |
| SCHEMBL17513184 | 0.66 | MEN1 (0.41) | HTR2AHTR2CHTR2BSLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787762-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha | ARCUS BIOSCIENCES, INC. (US) | 2023-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787762-B2 | Tetralin and tetrahydroquinoline compounds as inhibitors of HIF-2alpha | HIF1AN, HIF1A, EGLN2 | HTR2A 1033/4885HTR2C 699/4885HTR2B 2767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.