Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 3/20 | 0.60 |
| ▸ | CCND1 | P24385 | 3/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.60 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
| ▸ | MAP3K7 | O43318 | 6/20 | 0.57 |
| ▸ | MAP2K1 | Q02750 | 6/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.57 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 3/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
| ▸ | ULK1 | O75385 | 2/20 | 0.51 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.51 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.51 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | PLK1 | P53350 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26506563 | 0.93 | ULK1 (0.53) | CDK4CCND1CDK1CDK2MAP3K7 | |
| SCHEMBL26506540 | 0.91 | IGF1R (0.56) | MAP3K7MAP2K1MAPK1LCKEGFR | |
| SCHEMBL26506594 | 0.90 | LCK (0.56) | CDK4CCND1CDK1CDK2MAP3K7 | |
| SCHEMBL26506589 | 0.83 | ULK1 (0.59) | EGFRULK1PRKAA2PRKAA1ULK2 | |
| SCHEMBL26506579 | 0.83 | ULK1 (0.59) | CDK1CDK2KDREGFRULK1 | |
| SCHEMBL2961500 | 0.83 | BRD4 (0.57) | CDK4CCND1CDK1CDK2MAP3K7 | |
| SCHEMBL26506551 | 0.83 | ULK1 (0.61) | EGFRULK1PRKAA2PRKAA1ULK2 | |
| SCHEMBL26506580 | 0.83 | ULK1 (0.58) | CDK4CCND1CDK1CDK2KDR | |
| SCHEMBL26506558 | 0.81 | ULK1 (0.56) | CDK4CDK1CDK2KDREGFR | |
| SCHEMBL26506572 | 0.81 | ULK1 (0.56) | CDK1CDK2KDREGFRULK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230135635-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | Sanford Burnham Prebys Medical Discovery Institute | 2023-05-04 | — | — | US | disclosed |
| US-20230135635-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | Sanford Burnham Prebys Medical Discovery Institute | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230135635-A1 | INHIBITORS OF ULK1/2 AND METHODS OF USING SAME | ULK2, ULK1, ULK3 | CDK4 981/4885CCND1 4068/4885CDK1 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.