Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.60 |
| ▸ | PPARD | Q03181 | 1/20 | 0.60 |
| ▸ | PPARG | P37231 | 1/20 | 0.56 |
| ▸ | GCGR | P47871 | 12/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.51 |
| ▸ | GIPR | P48546 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652804 | 0.93 | PPARA (0.52) | PPARAPPARDPPARGGCGRROCK2 | |
| SCHEMBL2653591 | 0.85 | EPHX2 (0.56) | PPARAPPARDGCGRGIPR | |
| SCHEMBL20613278 | 0.82 | PPARA (0.64) | PPARAPPARDPPARG | |
| SCHEMBL2270623 | 0.81 | GCGR (0.59) | GCGRGIPR | |
| SCHEMBL2270627 | 0.81 | GCGR (0.59) | GCGRGIPR | |
| SCHEMBL2652102 | 0.80 | PPARD (0.49) | PPARAPPARDPPARGGCGRROCK2 | |
| SCHEMBL2652659 | 0.80 | PPARD (0.52) | PPARAPPARDPPARGGCGRROCK2 | |
| SCHEMBL2653422 | 0.80 | PPARD (0.51) | PPARAPPARDPPARGGCGR | |
| SCHEMBL2653894 | 0.79 | FFAR1 (0.48) | PPARAPPARDPPARGGCGRROCK2 | |
| SCHEMBL2661613 | 0.79 | MEN1 (0.55) | GCGRGIPRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | claimed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | claimed |
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |