Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 6/20 | 0.52 |
| ▸ | PPARD | Q03181 | 4/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GCGR | P47871 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 2/20 | 0.44 |
| ▸ | PTAFR | P25105 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651035 | 0.93 | PPARA (0.60) | PPARAPPARDROCK2ROCK1PPARG | |
| SCHEMBL2653990 | 0.82 | MEN1 (0.56) | ROCK2ROCK1MAPT | |
| SCHEMBL2654466 | 0.82 | MEN1 (0.56) | ROCK2ROCK1MAPT | |
| SCHEMBL2655916 | 0.81 | PPARD (0.49) | PPARAPPARDROCK2ROCK1PPARG | |
| SCHEMBL2654911 | 0.81 | MEN1 (0.47) | PPARAPPARDROCK2ROCK1PPARG | |
| SCHEMBL2652734 | 0.81 | MEN1 (0.57) | ROCK2ROCK1MAPT | |
| SCHEMBL2653250 | 0.81 | MEN1 (0.57) | ROCK2ROCK1MAPT | |
| SCHEMBL2653779 | 0.80 | ROCK2 (0.42) | PPARAPPARDROCK2ROCK1GCGR | |
| SCHEMBL2654640 | 0.80 | MEN1 (0.43) | PPARAPPARDROCK2ROCK1MAPT | |
| SCHEMBL2269762 | 0.80 | GCGR (0.53) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758859-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005118542-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-15 | — | — | WO | disclosed |