Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | OGA | O60502 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6702451 | 0.95 | TP53 (0.46) | TP53GAAAURKARXFP1SMN1; SMN2 | |
| SCHEMBL6697382 | 0.94 | TP53 (0.47) | TP53GAAAURKASMN1; SMN2NPC1 | |
| SCHEMBL1341110 | 0.87 | TP53 (0.47) | TP53GAAAURKARXFP1SMN1; SMN2 | |
| SCHEMBL1342960 | 0.87 | TP53 (0.47) | TP53GAAAURKASMN1; SMN2NPC1 | |
| SCHEMBL1343039 | 0.86 | TP53 (0.46) | TP53GAAAURKASMN1; SMN2NPC1 | |
| SCHEMBL1341790 | 0.85 | TP53 (0.48) | TP53GAAAURKARXFP1SMN1; SMN2 | |
| SCHEMBL1343466 | 0.85 | TP53 (0.45) | TP53GAAAURKASMN1; SMN2NPC1 | |
| SCHEMBL1343733 | 0.84 | TP53 (0.46) | TP53GAAAURKASMN1; SMN2NPC1 | |
| SCHEMBL2651341 | 0.84 | ALDH1A1 (0.44) | TP53GAAAURKARXFP1HSD17B10 | |
| SCHEMBL6700223 | 0.84 | TP53 (0.44) | TP53GAAAURKASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1531815-A1 | GLUCOKINASE ACTIVATORS | NOVO NORDISK A/S (DK) | 2005-05-25 | — | — | EP | disclosed |
| WO-2004002481-A1 | ARYL CARBONYL DERIVATIVES AS THERAPEUTIC AGENTS | NOVO NORDISK A/S (DK) | 2004-01-08 | — | — | WO | disclosed |