Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.42 |
| ▸ | ATF1 | P18846 | 1/20 | 0.42 |
| ▸ | STAT1 | P42224 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31521405 | 0.88 | L3MBTL1 (0.41) | L3MBTL1RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL23050297 | 0.82 | L3MBTL1 (0.39) | L3MBTL1RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL23050262 | 0.82 | L3MBTL1 (0.39) | L3MBTL1RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL13383758 | 0.82 | LMNA (0.48) | L3MBTL1RAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL14049462 | 0.80 | LMNA (0.47) | L3MBTL1RAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL13321131 | 0.78 | LMNA (0.48) | L3MBTL1RAB9ANPC1SMN1; SMN2CYP1A2 | |
| SCHEMBL7064550 | 0.76 | LMNA (0.47) | L3MBTL1RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL2658161 | 0.74 | L3MBTL1 (0.41) | L3MBTL1RAB9ANPC1SMN1; SMN2HPGD | |
| SCHEMBL19215234 | 0.74 | ATF1 (0.40) | L3MBTL1SMN1; SMN2ALDH1A1NFKB1ATF1 | |
| SCHEMBL13530701 | 0.74 | LMNA (0.42) | L3MBTL1RAB9ANPC1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004065388-A1 | FLUOROIMIDAZOPYRIMIDINES AS GABA-A ALPHA 2/3 LIGANDS FOR DEPRESSION/ANXIETY | MERCK SHARP & DOHME LIMITED (GB) | 2004-08-05 | — | — | WO | disclosed |