Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 9/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.39 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.37 |
| ▸ | STAT1 | P42224 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | ATF1 | P18846 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2651522 | 0.74 | L3MBTL1 (0.46) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL20843728 | 0.67 | L3MBTL1 (0.52) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL994563 | 0.67 | RAB9A (0.55) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL8710366 | 0.66 | RAB9A (0.52) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL7064550 | 0.66 | LMNA (0.47) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL30152021 | 0.65 | XDH (0.46) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL31521405 | 0.65 | L3MBTL1 (0.41) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL25194875 | 0.64 | L3MBTL1 (0.39) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL22208162 | 0.64 | ALDH1A1 (0.49) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD | |
| SCHEMBL3270375 | 0.64 | RAB9A (0.56) | L3MBTL1RAB9ASMN1; SMN2NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004065388-A1 | FLUOROIMIDAZOPYRIMIDINES AS GABA-A ALPHA 2/3 LIGANDS FOR DEPRESSION/ANXIETY | MERCK SHARP & DOHME LIMITED (GB) | 2004-08-05 | — | — | WO | disclosed |