Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | PNLIP | P16233 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TSPO | P30536 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842794 | 0.82 | IRAK4 (0.45) | SLC6A3MAPTKMT2AHTTIRAK4 | |
| SCHEMBL7795902 | 0.82 | IRAK4 (0.51) | SLC6A3MAPTKMT2AIRAK4GAA | |
| SCHEMBL15897488 | 0.81 | SLC6A3 (0.60) | SLC6A3MAPTKMT2AHTTMEN1 | |
| SCHEMBL2651842 | 0.80 | NR4A2 (0.41) | SLC6A3MAPTKMT2AMEN1PNLIP | |
| SCHEMBL7838547 | 0.78 | TSHR (0.43) | SLC6A3MAPTKMT2AHTTMEN1 | |
| SCHEMBL15880926 | 0.76 | SLC6A3 (0.48) | SLC6A3MAPTKMT2AHTTSMN1; SMN2 | |
| SCHEMBL12313575 | 0.73 | CXCR5 (0.52) | MAPTKMT2AMEN1IRAK4GAA | |
| SCHEMBL5331876 | 0.73 | TSHR (0.58) | MAPTKMT2APNLIPIRAK4GAA | |
| SCHEMBL17703257 | 0.72 | HSD17B10 (0.52) | SLC6A3MAPTKMT2AHTTMEN1 | |
| SCHEMBL7755868 | 0.71 | LMNA (0.51) | SLC6A3MAPTKMT2AHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718625-A1 | COMPOUNDS | AstraZeneca AB (SE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005080360-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |