Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15933475 | 0.76 | PDCD1 (0.41) | PDCD1CD274 | |
| SCHEMBL4234253 | 0.76 | PDCD1 (0.48) | PDCD1CD274 | |
| SCHEMBL20792880 | 0.76 | PDCD1 (0.41) | PDCD1CD274 | |
| Hydrochloric Acid SCHEMBL20141433 | 0.74 | PDCD1 (0.40) | PDCD1CD274 | |
| SCHEMBL4237524 | 0.73 | PDCD1 (0.43) | PDCD1CD274 | |
| SCHEMBL24687617 | 0.72 | PDCD1 (0.42) | PDCD1CD274 | |
| SCHEMBL1620214 | 0.72 | PDCD1 (0.39) | PDCD1CD274 | |
| SCHEMBL20319383 | 0.72 | PDCD1 (0.42) | PDCD1CD274 | |
| SCHEMBL15933523 | 0.72 | PDCD1 (0.42) | PDCD1CD274 | |
| SCHEMBL13931060 | 0.72 | PDCD1 (0.39) | PDCD1CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1121361-B1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME (GB) | 2007-08-29 | — | — | EP | disclosed |
| US-20030060467-A1 | Pyrazolo-triazine derivatives as ligands for gaba receptors | MERCK SHARP & DOHME LTD. (GB) | 2003-03-27 | — | — | US | disclosed |
| US-6476030-B1 | Pyrazolo-triazine derivatives as ligands for GABA receptors | MERCK SHARP & DOHME LTD. | 2002-11-05 | — | — | US | disclosed |
| EP-1121361-A1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | Merck Sharp & Dohme Limited (GB) | 2001-08-08 | — | — | EP | disclosed |
| WO-2000023449-A1 | PYRAZOLO-TRIAZINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2000-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030060467-A1 | Pyrazolo-triazine derivatives as ligands for gaba receptors | GABRA5, GABRA3, GABRA4 | PDCD1 1125/4885CD274 1746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.