Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | DPEP1 | P16444 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CHAT | P28329 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8669221 | 0.74 | RELA (0.43) | ALDH1A1SLC6A3SLC6A4SLC6A2KCNH2 | |
| SCHEMBL6987167 | 0.72 | ALDH1A1 (0.39) | ALDH1A1DPEP1 | |
| SCHEMBL23093933 | 0.71 | HSD17B10 (0.44) | — | |
| SCHEMBL497968 | 0.71 | KDM4E (0.42) | ALDH1A1MAPK1HPGD | |
| SCHEMBL8227101 | 0.70 | ALDH1A1 (0.45) | ALDH1A1DPEP1MAPK1CHATSLC6A3 | |
| SCHEMBL10985072 | 0.70 | RAB9A (0.41) | ALDH1A1DPEP1SLC6A3 | |
| SCHEMBL27851021 | 0.70 | RAB9A (0.41) | ALDH1A1HPGD | |
| SCHEMBL4420128 | 0.70 | ALDH1A1 (0.60) | ALDH1A1CHATPYGL | |
| SCHEMBL28208720 | 0.69 | KDM4E (0.45) | ALDH1A1MAPK1SIGMAR1 | |
| SCHEMBL28208059 | 0.69 | KDM4E (0.45) | ALDH1A1MAPK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | claimed |
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | disclosed |