Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL6194671 | 0.91 | PNMT (0.52) | PNMTTAAR1SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL7097984 | 0.89 | IGF1R (0.49) | PNMTTAAR1SIGMAR1ALDH1A1MAPT | |
| SCHEMBL20405360 | 0.81 | SIGMAR1 (0.43) | SIGMAR1ALDH1A1MAPTSMN1; SMN2OPRK1 | |
| SCHEMBL21788431 | 0.79 | POLB (0.49) | PNMTTAAR1SIGMAR1SMN1; SMN2SLC6A2 | |
| SCHEMBL25787111 | 0.79 | POLB (0.49) | PNMTTAAR1SIGMAR1SMN1; SMN2SLC6A2 | |
| SCHEMBL21622788 | 0.77 | MAOB (0.55) | TAAR1ALDH1A1CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL9262567 | 0.77 | PNMT (0.39) | PNMTTAAR1SIGMAR1ALDH1A1MAPT | |
| SCHEMBL9262557 | 0.77 | PNMT (0.39) | PNMTTAAR1SIGMAR1ALDH1A1MAPT | |
| SCHEMBL9627994 | 0.75 | SIGMAR1 (0.38) | PNMTTAAR1SIGMAR1ALDH1A1MAPT | |
| SCHEMBL9260158 | 0.75 | SIGMAR1 (0.38) | PNMTTAAR1SIGMAR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | claimed |
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | disclosed |