Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL697179 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL9275621 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL1931178 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL8027671 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL6028274 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL5556136 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL6554416 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL4458809 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL10709971 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL1836225 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1710240-B1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | SERVIER LAB (FR) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006106241-A1 | PIPERAZINE DERIVATIVES AND USE THEREOF AS SEROTONIN REUPTAKE INHIBITORS OR AS NEUROKININ ANTAGONISTS | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | WO | disclosed |
| EP-1710240-A1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | Les Laboratoires Servier (FR) | 2006-10-11 | — | — | EP | disclosed |
| WO-2004063194-A1 | HETEROARYL COMPOUNDS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |
| EP-0566557-B1 | 2- and 3- amino and azido derivatives of 1,5-iminosugars as antiviral compounds | SEARLE & CO (US) | 1996-09-04 | — | — | EP | disclosed |
| US-5550243-A | ACYLATING DEOXYNOJIRIMYCIN, PROTECTING C-4 AND C-6 HYDROXYLS BY ACETALIZATION OR KETALIZATION, SULFONYLATING HYDROXYL AT C-2, FORMING EPOXIDE AT C-2 AND C-3, OPENING EPOXIDE BY NUCLEOPHILIC ATTACK WITH AZIDE COMPOUND | G. D. SEARLE & CO. (US) | 1996-08-27 | — | — | US | disclosed |
| US-5436341-A | Intermediates for 2,3-diamino-1,5-iminosugars | G. D. SEARLE & CO. (US) | 1995-07-25 | — | — | US | disclosed |
| US-5391746-A | Inhibitors of lentiviruses; deoxynojirimycin derivatives | G. D. SEARLE & CO. (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0539486-B1 | PROCESS FOR THE PREPARATION OF STREPTOGRAMINE DERIVATIVES | RHONE POULENC RORER SA (FR) | 1994-09-28 | — | — | EP | disclosed |
| US-5334717-A | Inhibit lentiviruses | G. D. SEARLE & CO. (US) | 1994-08-02 | — | — | US | disclosed |
| US-5270468-A | 2- and 3- amino azido derivatives of 1,5-iminosugars | G. D. SEARLE & CO. (US) | 1993-12-14 | — | — | US | disclosed |
| US-5216168-A | Lentivirus inhibitors | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0539486-A1 | PROCESS FOR THE PREPARATION OF STREPTOGRAMINE DERIVATIVES. | RHONE POULENC RORER SA (FR) | 1993-05-05 | — | — | EP | disclosed |
| US-5206251-A | Viricide | G. D. SEARLE & CO. (US) | 1993-04-27 | — | — | US | disclosed |
| WO-1992001691-A1 | NEW DERIVATIVES OF STREPTOGRAMINES AND PREPARATION THEREOF | RHONE-POULENC RORER S.A. (FR) | 1992-02-06 | — | — | WO | disclosed |
| US-4644004-A | Pyridynecarboxylic esters of dopamine and of its N-alkyl derivatives | SIMES S.P.A. (IT) | 1987-02-17 | — | — | US | disclosed |
| EP-0101633-B1 | PYRIDINECARBOXYLIC ESTERS OF DOPAMINE AND OF ITS N-ALKYL DERIVATIVES | Simes S.p.A. (IT) | 1986-12-03 | — | — | EP | disclosed |
| EP-0101633-A1 | Pyridinecarboxylic esters of dopamine and of its N-alkyl derivatives | Simes S.p.A. (IT) | 1984-02-29 | — | — | EP | disclosed |