Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | TSHR | P16473 | 3/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Alcohol SCHEMBL9275621 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL1931178 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL8027671 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL6028274 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL5556136 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL6554416 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL4458809 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL2652301 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL10709971 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 | |
| Alcohol SCHEMBL1836225 | 1.00 | ALDH1A1 (0.67) | ALDH1A1TSHRTDP1HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101398489-B | Optical film, polarizing plate and image display device | FUJIFILM CORP | 2012-07-11 | — | — | CN | disclosed |
| EP-2423207-A2 | 2-(cyclic amino)-pyrimidone derivatives as TPK1 inhibitors | Mitsubishi Tanabe Pharma Corporation (JP) | 2012-02-29 | — | — | EP | disclosed |
| CN-101398489-A | Optical film, polarizing plate and image display device | FUJIFILM CORP (JP) | 2009-04-01 | — | — | CN | disclosed |
| EP-2001863-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-12-17 | — | — | EP | disclosed |
| EP-1660085-B1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007119463-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-10-25 | — | — | WO | disclosed |
| US-7081468-B2 | Ortho-substituted anthranilic acid amides and their use as medicaments | SCHERING AG (DE) | 2006-07-25 | — | — | US | disclosed |
| EP-1660085-A1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2006-05-31 | — | — | EP | disclosed |
| US-20060014747-A1 | Ortho-substituted anthranilic acid amides and their use as pharmaceutical agents | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2006-01-19 | — | — | US | disclosed |
| US-20050043346-A1 | Pyridylpyrrole derivatives active as kinase inhibitors | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-24 | — | — | US | disclosed |
| WO-2005013986-A1 | PYRIDYLPYRROLE DERIVATIVES ACTIVE AS KINASE INHIBITORS | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-17 | — | — | WO | disclosed |
| EP-0751144-B1 | Novel anthracycline prodrugs, method for preparation as well as their use in selective chemotherapy | PHARMACHEMIE BV (NL) | 2004-10-06 | — | — | EP | disclosed |
| US-20040102441-A1 | Ortho-substituted anthranilic acid amides and their use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2004-05-27 | — | — | US | disclosed |
| US-5710135-A | ENZYMATICALLY CLEAVABLE; ANTITUMOR AGENTS | PHARMACHEMIE B.V. (NL) | 1998-01-20 | — | — | US | disclosed |
| EP-0751144-A1 | Novel anthracycline prodrugs, method for preparation as well as their use in selective chemotherapy | PHARMACHEMIE B.V. (NL) | 1997-01-02 | — | — | EP | disclosed |
| WO-1996012725-A1 | NOVEL QUINOXALINDIONE DERIVATIVES, THEIR PRODUCTION AND USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-05-02 | — | — | WO | disclosed |
| US-5403572-A | Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-04-04 | — | — | US | disclosed |
| US-5334371-A | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043346-A1 | Pyridylpyrrole derivatives active as kinase inhibitors | MAP3K6, MAP3K5, MAP4K2 | ALDH1A1 2319/4885TSHR 1858/4885TDP1 1002/4885 |
| US-20060014747-A1 | Ortho-substituted anthranilic acid amides and their use as pharmaceutical agents | VEGFA, TEK, OGFR | ALDH1A1 1187/4885TSHR 1553/4885TDP1 4694/4885 |
| US-20040102441-A1 | Ortho-substituted anthranilic acid amides and their use as medicaments | TEK, VEGFA, ASPH | ALDH1A1 1414/4885TSHR 2181/4885TDP1 4647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.