Sugi Predict

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SCHEMBL265237

SCHEMBL265237

Cc1ccc(C=NNC(=O)c2c(NC(=O)c3cccc(CN(CC(C)O)CC(C)O)c3)sc3ccccc23)cc1C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC34A2 O95436 8/20 0.39
▸ TSHR P16473 1/20 0.37
▸ RECQL P46063 1/20 0.37
▸ LMNA P02545 3/20 0.37
▸ MAPT P10636 3/20 0.37
▸ SMN1; SMN2 Q16637 3/20 0.37
▸ HPGD P15428 3/20 0.37
▸ KDM4E B2RXH2 2/20 0.37
▸ ALDH1A1 P00352 2/20 0.37
▸ PLK1 P53350 1/20 0.36
▸ RAB9A P51151 4/20 0.36
▸ NPC1 O15118 3/20 0.36
▸ NFKB1 P19838 1/20 0.36
▸ NFKB2 Q00653 1/20 0.36
▸ RELA Q04206 1/20 0.36
▸ POLB P06746 2/20 0.35
▸ BLM P54132 1/20 0.35
▸ CTDSP1 Q9GZU7 1/20 0.35
▸ CASP3 P42574 1/20 0.35
▸ SENP8 Q96LD8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL265236 1.00 SLC34A2 (0.39) SLC34A2TSHRRECQLLMNAMAPT
SCHEMBL268263 0.92 NPC1 (0.42) SLC34A2TSHRRECQLLMNAMAPT
SCHEMBL268262 0.92 NPC1 (0.42) SLC34A2TSHRRECQLLMNAMAPT
SCHEMBL269804 0.90 OGG1 (0.45) SLC34A2TSHRRECQLLMNAMAPT
SCHEMBL269805 0.90 OGG1 (0.45) SLC34A2TSHRRECQLLMNAMAPT
SCHEMBL267500 0.89 XBP1 (0.45) SLC34A2TSHRRECQLLMNAMAPT
SCHEMBL267501 0.89 XBP1 (0.45) SLC34A2TSHRRECQLLMNAMAPT
SCHEMBL269187 0.89 MAPT (0.43) SLC34A2LMNAMAPTSMN1; SMN2HPGD
SCHEMBL269186 0.89 MAPT (0.43) SLC34A2LMNAMAPTSMN1; SMN2HPGD
SCHEMBL267474 0.88 SLC34A2 (0.41) SLC34A2TSHRRECQLLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-05-10 — — US disclosed
US-8134015-B2 Compound inhibiting in vivo phosphorous transport and medicine containing the same KYOWA HAKKO KIRIN CO., LTD. (JP) 2012-03-13 — — US disclosed
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same KIRIN BEER KABUSHIKI KAISHA (JP) 2006-09-28 — — US disclosed
EP-1614676-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME KIRIN BEER KABUSHIKI KAISHA (JP) 2006-01-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060217426-A1 Compound inhibiting in vivo phosphorous transport and medicine containing the same SLC10A6, SLC7A1, SLC10A1 SLC34A2 6/4885TSHR 729/4885RECQL 1619/4885
US-20120115851-A1 COMPOUND INHIBITING IN VIVO PHOSPHORUS TRANSPORT AND MEDICINE CONTAINING THE SAME SLC34A1, SLC34A2, SLC20A2 SLC34A2 2/4885TSHR 487/4885RECQL 1515/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.