Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655431 | 0.89 | EPHX2 (0.47) | PPARDPPARAPLA2G4BMLYCD | |
| SCHEMBL2653990 | 0.86 | MEN1 (0.56) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2654466 | 0.86 | MEN1 (0.56) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2653250 | 0.85 | MEN1 (0.57) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2652734 | 0.85 | MEN1 (0.57) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2653962 | 0.84 | MEN1 (0.58) | MEN1KMT2AROCK2ROCK1ALDH1A1 | |
| SCHEMBL2653779 | 0.83 | ROCK2 (0.42) | MEN1KMT2AROCK2ROCK1ESRRG | |
| SCHEMBL2654871 | 0.81 | SLC13A5 (0.45) | MLYCD | |
| SCHEMBL2655689 | 0.81 | MEN1 (0.50) | MEN1KMT2AROCK2ROCK1NPC1 | |
| SCHEMBL2652804 | 0.80 | PPARA (0.52) | ROCK2ROCK1PPARDPPARAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |