Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 7/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | GCG | P01275 | 7/20 | 0.38 |
| ▸ | ADCY6 | O43306 | 2/20 | 0.37 |
| ▸ | ADCY3 | O60266 | 2/20 | 0.37 |
| ▸ | ADCY9 | O60503 | 2/20 | 0.37 |
| ▸ | ADCY5 | O95622 | 2/20 | 0.37 |
| ▸ | ADCY8 | P40145 | 2/20 | 0.37 |
| ▸ | ADCY7 | P51828 | 2/20 | 0.37 |
| ▸ | ADCY2 | Q08462 | 2/20 | 0.37 |
| ▸ | ADCY1 | Q08828 | 2/20 | 0.37 |
| ▸ | ADCY4 | Q8NFM4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2650549 | 0.92 | MAPT (0.42) | GCGRSMN1; SMN2MAPTALDH1A1ALOX12 | |
| SCHEMBL2650935 | 0.88 | GCGR (0.53) | GCGRSMN1; SMN2GCGACKR3GLP1R | |
| SCHEMBL2661495 | 0.86 | MAPT (0.42) | GCGRSMN1; SMN2MAPTALDH1A1ALOX12 | |
| SCHEMBL2652873 | 0.86 | ALDH1A1 (0.39) | GCGRSMN1; SMN2MAPTALDH1A1ALOX12 | |
| SCHEMBL2650883 | 0.86 | GCGR (0.49) | GCGRSMN1; SMN2MAPTALDH1A1ALOX12 | |
| SCHEMBL2650553 | 0.84 | ALDH1A1 (0.42) | GCGRSMN1; SMN2MAPTALDH1A1ALOX12 | |
| SCHEMBL2652865 | 0.82 | GCGR (0.58) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL2661497 | 0.81 | ALDH1A1 (0.42) | GCGRSMN1; SMN2MAPTALDH1A1ALOX12 | |
| SCHEMBL6748418 | 0.80 | GCGR (0.48) | GCGRSMN1; SMN2MAPTALDH1A1ADCY6 | |
| SCHEMBL2651127 | 0.79 | L3MBTL1 (0.41) | GCGRMAPTALDH1A1GCGMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127560-A1 | Glucagon antagonists/inverse agonists | MADSEN PETER (DK) | 2004-07-01 | — | — | US | claimed |
| US-6706744-B2 | HYPOGLYCEMIC AGENTS; ANTIDIABETIC AGENTS | NOVO NORDISK A/S (DK) | 2004-03-16 | — | — | US | claimed |
| US-20030065031-A1 | Glucagon antagonists/inverse agonists | PFIZER INC | 2003-04-03 | — | — | US | claimed |
| WO-2002040444-A1 | GLUCAGON ANTAGONISTS/INVERSE AGONISTS | NOVO NORDISK A/S (DK) | 2002-05-23 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127560-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | GCGR 3/4885SMN1; SMN2 3651/4885MAPT 4386/4885 |
| US-20030065031-A1 | Glucagon antagonists/inverse agonists | GLP1R, GPR119, GCGR | GCGR 3/4885SMN1; SMN2 3651/4885MAPT 4386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.