Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MET | P08581 | 9/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26529105 | 0.86 | MET (0.40) | MAPTSMN1; SMN2MEN1KMT2AMET | |
| SCHEMBL26529054 | 0.81 | MET (0.46) | MEN1KMT2AMETPDE4APDE4B | |
| SCHEMBL26529073 | 0.80 | MEN1 (0.35) | MAPTSMN1; SMN2MEN1KMT2AMET | |
| SCHEMBL26999000 | 0.79 | MAPT (0.39) | MAPTSMN1; SMN2MEN1KMT2AMET | |
| SCHEMBL26999063 | 0.79 | MET (0.52) | MAPTSMN1; SMN2MEN1KMT2AMET | |
| SCHEMBL23558978 | 0.79 | MEN1 (0.41) | MAPTSMN1; SMN2MEN1KMT2AMET | |
| SCHEMBL29569742 | 0.79 | MEN1 (0.41) | MAPTSMN1; SMN2MEN1KMT2AMET | |
| SCHEMBL29569490 | 0.78 | MET (0.43) | MEN1KMT2AMETTP53PDE4A | |
| SCHEMBL23528280 | 0.78 | MET (0.43) | MEN1KMT2AMETTP53PDE4A | |
| SCHEMBL26530932 | 0.78 | MET (0.43) | MAPTMEN1KMT2AMETTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230321091-A1 | SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES | EDGEWISE THERAPEUTICS, INC. | 2023-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230321091-A1 | SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES | IL6, MUSK, SMN1; SMN2 | MAPT 1863/4885SMN1; SMN2 3/4885MEN1 4467/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.