Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.40 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.40 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.40 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29967703 | 1.00 | MAPK1 (0.46) | MAPK1L3MBTL1KDM4EHPGDNPSR1 | |
| SCHEMBL2569037 | 0.81 | ALDH1A1 (0.44) | MAPK1L3MBTL1KDM4EHPGDNPSR1 | |
| SCHEMBL6695094 | 0.81 | ADORA1 (0.40) | MAPK1KDM4EHPGDNPSR1RXFP1 | |
| SCHEMBL16122421 | 0.80 | ALDH1A1 (0.42) | MAPK1L3MBTL1KDM4EHPGDNPSR1 | |
| SCHEMBL28871241 | 0.79 | ALDH1A1 (0.43) | MAPK1L3MBTL1KDM4EHPGDALDH1A1 | |
| SCHEMBL421377 | 0.79 | ALDH1A1 (0.41) | MAPK1L3MBTL1KDM4EHPGDNPSR1 | |
| SCHEMBL9854261 | 0.78 | SQOR (0.40) | MAPK1L3MBTL1KDM4EHPGDNPSR1 | |
| SCHEMBL4958212 | 0.78 | ALDH1A1 (0.53) | MAPK1L3MBTL1KDM4EHPGDNPSR1 | |
| SCHEMBL16122425 | 0.77 | ADORA1 (0.51) | MAPK1L3MBTL1KDM4EHPGDNPSR1 | |
| SCHEMBL29052685 | 0.77 | ADORA1 (0.49) | MAPK1L3MBTL1KDM4EHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115260165-A | Benzo nitrogen-containing five-membered heterocyclic compound and synthesis and application thereof | 中国科学院上海药物研究所 | 2022-11-01 | — | — | CN | disclosed |
| EP-1381606-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2004-01-21 | — | — | EP | disclosed |
| WO-2002074773-A1 | IMIDAZO-PYRIMIDINE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2002-09-26 | — | — | WO | disclosed |