Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 9/20 | 0.56 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.56 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652925 | 0.89 | NPC1 (0.49) | S1PR1S1PR3S1PR5NPC1RAB9A | |
| SCHEMBL2654896 | 0.86 | S1PR1 (0.60) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2657107 | 0.86 | S1PR1 (0.66) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2656631 | 0.85 | NPC1 (0.67) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2654883 | 0.85 | NPC1 (0.67) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2654768 | 0.83 | S1PR1 (0.66) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2653847 | 0.83 | NPC1 (0.57) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2654580 | 0.83 | S1PR1 (0.56) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2662580 | 0.83 | S1PR1 (0.56) | S1PR1S1PR3S1PR5FFAR1NPC1 | |
| SCHEMBL2656519 | 0.83 | S1PR1 (0.56) | S1PR1S1PR3S1PR5FFAR1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |