Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 12/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23528336 | 0.84 | GRIN2B (0.44) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL30568693 | 0.84 | GRIN2B (0.44) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL26527935 | 0.79 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL26530187 | 0.79 | GRIN1 (0.45) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL26527929 | 0.79 | GRIN2B (0.44) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL26529132 | 0.77 | GRIN2B (0.44) | PDE4APDE4BPDE4CPDE4DMET | |
| SCHEMBL29569798 | 0.77 | GRIN2B (0.50) | METGRIN1GRIN2BMEN1KMT2A | |
| SCHEMBL23528379 | 0.77 | GRIN2B (0.50) | METGRIN1GRIN2BMEN1KMT2A | |
| SCHEMBL23558969 | 0.76 | GRIN2B (0.51) | PDE4APDE4BPDE4CPDE4DGRIN1 | |
| SCHEMBL26522355 | 0.75 | MET (0.43) | PDE4APDE4BPDE4CPDE4DMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230321091-A1 | SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES | EDGEWISE THERAPEUTICS, INC. | 2023-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230321091-A1 | SUBSTITUTED PYRIDAZINONES FOR USE IN THE TREATMENT OF NEUROMUSCULAR DISEASES | IL6, MUSK, SMN1; SMN2 | PDE4A 305/4885PDE4B 618/4885PDE4C 634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.