Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 1/20 | 0.37 |
| ▸ | PGK2 | P07205 | 1/20 | 0.37 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13199152 | 0.87 | PGK1 (0.42) | PGK1PGK2CNR1CNR2IDH1 | |
| SCHEMBL31306520 | 0.85 | CA12 (0.38) | KRASSOS1 | |
| SCHEMBL26806630 | 0.78 | TSHR (0.46) | PGK1PGK2CNR1CNR2 | |
| SCHEMBL172763 | 0.76 | RAPGEF4 (0.44) | PGK1PGK2ACHEIDH1 | |
| SCHEMBL27187317 | 0.76 | NOTUM (0.32) | — | |
| SCHEMBL29799823 | 0.76 | NOTUM (0.32) | — | |
| SCHEMBL29799778 | 0.74 | RXRA (0.38) | ACHE | |
| SCHEMBL27186673 | 0.74 | RXRA (0.38) | ACHE | |
| SCHEMBL15147437 | 0.74 | PGK1 (0.38) | PGK1PGK2ACHE | |
| SCHEMBL29799787 | 0.73 | KRAS (0.39) | KRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023180345-A1 | TRICYCLIC PHTHALAZINES AND DERIVATIVES AS SOS1 INHIBITORS | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2023-09-28 | — | — | WO | disclosed |