Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 10/20 | 0.37 |
| ▸ | GCGR | P47871 | 3/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
| ▸ | POLQ | O75417 | 1/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2652622 | 0.93 | GCGR (0.42) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2653672 | 0.91 | GCGR (0.39) | HDAC1HDAC6EPHX2GCGRPPARD | |
| SCHEMBL2653233 | 0.89 | GCGR (0.43) | EPHX2GCGR | |
| SCHEMBL2654006 | 0.88 | GCGR (0.35) | GCGR | |
| SCHEMBL2654266 | 0.85 | GCGR (0.43) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL2653132 | 0.84 | GCGR (0.46) | GCGRPPARD | |
| SCHEMBL2653014 | 0.84 | SMN1; SMN2 (0.36) | EPHX2 | |
| SCHEMBL2654086 | 0.83 | GCGR (0.40) | EPHX2GCGRPPARD | |
| SCHEMBL2653071 | 0.83 | GCGR (0.39) | EPHX2GCGRPPARD | |
| SCHEMBL2653251 | 0.82 | GCGR (0.37) | HDAC3HDAC4HDAC1HDAC6EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |