Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 4/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | VDR | P11473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | ADCY6 | O43306 | 1/20 | 0.31 |
| ▸ | ADCY3 | O60266 | 1/20 | 0.31 |
| ▸ | ADCY9 | O60503 | 1/20 | 0.31 |
| ▸ | ADCY5 | O95622 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653672 | 0.93 | GCGR (0.39) | GCGRMAPTSMN1; SMN2EPHX2MCL1 | |
| SCHEMBL2654374 | 0.92 | GCGR (0.51) | GCGRACKR3VDRKMT2AADCY6 | |
| SCHEMBL2652401 | 0.90 | GCGR (0.35) | GCGRACKR3VDRL3MBTL1NPC1 | |
| SCHEMBL2654006 | 0.90 | GCGR (0.35) | GCGRMAPTS1PR1S1PR3SMN1; SMN2 | |
| SCHEMBL2653090 | 0.89 | HDAC3 (0.38) | GCGREPHX2 | |
| SCHEMBL2666495 | 0.88 | GCGR (0.44) | GCGRACKR3VDRMAPTL3MBTL1 | |
| SCHEMBL2654238 | 0.86 | GCGR (0.43) | GCGRACKR3VDRMAPTL3MBTL1 | |
| SCHEMBL2654671 | 0.86 | GCGR (0.39) | GCGRACKR3VDRMAPTMEN1 | |
| SCHEMBL2652524 | 0.86 | GCGR (0.36) | GCGRACKR3MAPTNPC1POLB | |
| SCHEMBL2654872 | 0.85 | GCGR (0.42) | GCGRACKR3VDRMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |