Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 3/20 | 0.42 |
| ▸ | VDR | P11473 | 2/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARD | Q03181 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | ESRRG | P62508 | 2/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGAV | P06756 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | ESRRB | O95718 | 1/20 | 0.30 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653335 | 0.93 | GCGR (0.50) | GCGRVDRACKR3KMT2AMCL1 | |
| SCHEMBL2654748 | 0.88 | GCGR (0.37) | GCGRHPGDMAPTPPARGPPARD | |
| SCHEMBL2654238 | 0.87 | GCGR (0.43) | GCGRVDRACKR3HPGDMAPT | |
| SCHEMBL2653812 | 0.86 | GCGR (0.42) | GCGRVDRACKR3HPGDMAPT | |
| SCHEMBL2653233 | 0.85 | GCGR (0.43) | GCGRVDRACKR3MAPTMEN1 | |
| SCHEMBL2652386 | 0.85 | GCGR (0.42) | GCGRVDRACKR3HPGDMAPT | |
| SCHEMBL2666495 | 0.85 | GCGR (0.44) | GCGRVDRACKR3MAPTMEN1 | |
| SCHEMBL2654307 | 0.85 | HPGD (0.43) | GCGRVDRACKR3HPGDMAPT | |
| SCHEMBL2654750 | 0.84 | GCGR (0.38) | GCGRHPGDMAPTPPARGPPARD | |
| SCHEMBL2652385 | 0.84 | GCGR (0.43) | GCGRVDRACKR3MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |