Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | CCND3 | P30281 | 1/20 | 0.43 |
| ▸ | MAPK4 | P31152 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1564971 | 0.84 | MAPT (0.50) | MAPTKDM4EPOLBFFAR2TSHR | |
| SCHEMBL1565595 | 0.83 | MAPT (0.47) | MAPTKDM4EPOLBFFAR2L3MBTL1 | |
| SCHEMBL2653273 | 0.82 | MAPT (0.50) | MAPTKDM4EPOLBFFAR2L3MBTL1 | |
| SCHEMBL1565355 | 0.78 | TDP1 (0.56) | MAPTTSHRMAPK1ALDH1A1 | |
| SCHEMBL1565282 | 0.78 | POLB (0.48) | MAPTKDM4EPOLBFFAR2TSHR | |
| SCHEMBL2655095 | 0.78 | ALDH1A1 (0.48) | MAPTKDM4EPOLBFFAR2L3MBTL1 | |
| SCHEMBL1565387 | 0.77 | MAPT (0.52) | MAPTKDM4EPOLBFFAR2L3MBTL1 | |
| SCHEMBL1565806 | 0.74 | MAPT (0.49) | MAPTKDM4EPOLBFFAR2TSHR | |
| SCHEMBL2651656 | 0.74 | FFAR2 (0.73) | MAPTKDM4EPOLBFFAR2TSHR | |
| SCHEMBL1565141 | 0.73 | MAPT (0.50) | MAPTKDM4EPOLBFFAR2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | claimed |