Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 15/20 | 0.39 |
| ▸ | GCG | P01275 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GIPR | P48546 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653891 | 0.84 | GCGR (0.42) | GCGRGCGKMT2AGIPRMCL1 | |
| SCHEMBL2654671 | 0.81 | GCGR (0.39) | GCGRKMT2AMCL1 | |
| SCHEMBL2654683 | 0.81 | GCGR (0.46) | GCGRGCGKMT2AGIPRMCL1 | |
| SCHEMBL2656044 | 0.81 | GCGR (0.42) | GCGRGIPRMCL1 | |
| SCHEMBL2661440 | 0.81 | PPARD (0.37) | GCGRGIPRMCL1 | |
| SCHEMBL2653438 | 0.79 | GCG (0.41) | GCGRGCGKMT2AGIPRMCL1 | |
| SCHEMBL2653436 | 0.79 | GCG (0.41) | GCGRGCGKMT2AGIPRMCL1 | |
| SCHEMBL2653953 | 0.78 | GCGR (0.43) | GCGRGCGKMT2AGIPRMCL1 | |
| SCHEMBL2653332 | 0.77 | GCGR (0.46) | GCGRGCGKMT2AGIPRMCL1 | |
| SCHEMBL2653101 | 0.77 | GCGR (0.42) | GCGRGCGKMT2AGIPRMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | claimed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | claimed |
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |