Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.48 |
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | METAP1 | P53582 | 4/20 | 0.48 |
| ▸ | CCR1 | P32246 | 2/20 | 0.48 |
| ▸ | CCR5 | P51681 | 2/20 | 0.48 |
| ▸ | CCR8 | P51685 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.48 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.44 |
| ▸ | PKM | P14618 | 4/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046862 | 0.73 | MEN1 (0.55) | KDM4ELMNACYP1A2POLBNPY5R | |
| SCHEMBL403894 | 0.71 | MTOR (0.43) | KDM4ECYP1A2NPY5RNPC1RAB9A | |
| SCHEMBL2476969 | 0.71 | KDM4E (0.50) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL30403779 | 0.71 | KDM4E (0.50) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL16817999 | 0.69 | MTOR (0.57) | KDM4ELMNAMETAP1CCR1CCR5 | |
| SCHEMBL5478697 | 0.69 | KDM4E (0.59) | KDM4ELMNAMETAP1CCR1CCR5 | |
| Dipyridyl SCHEMBL29351528 | 0.68 | KDM4E (1.00) | KDM4ELMNAMETAP1CCR1CCR5 | |
| Dipyridyl SCHEMBL29907716 | 0.68 | KDM4E (1.00) | KDM4ELMNAMETAP1CCR1CCR5 | |
| Dipyridyl SCHEMBL3711450 | 0.68 | KDM4E (1.00) | KDM4ELMNAMETAP1CCR1CCR5 | |
| Dipyridyl SCHEMBL5922 | 0.68 | KDM4E (1.00) | KDM4ELMNAMETAP1CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1635813-A4 | COMBINATION THERAPY FOR THE TREATMENT OF DYSLIPIDEMIA | MERCK & CO INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1799241-A2 | COMBINATION THERAPY FOR THE TREATMENT OF OBESITY | Merck & Co., Inc. (US) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006036770-A2 | COMBINATION THERAPY FOR THE TREATMENT OF OBESITY | MERCK & CO., INC. (US) | 2006-04-06 | — | — | WO | disclosed |
| EP-1635832-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES | Merck & Co., Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1635813-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DYSLIPIDEMIA | Merck & Co. Inc. (US) | 2006-03-22 | — | — | EP | disclosed |
| EP-1635773-A2 | COMBINATION THERAPY FOR THE TREATMENT OF HYPERTENSION | Merck & Co., Inc. (a New Jersey corp.) (US) | 2006-03-22 | — | — | EP | disclosed |
| WO-2005000217-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DYSLIPIDEMIA | MERCK & CO., INC. (US) | 2005-01-06 | — | — | WO | disclosed |
| WO-2004110375-A2 | COMBINATION THERAPY FOR THE TREATMENT OF DIABETES | MERCK & CO., INC. (US) | 2004-12-23 | — | — | WO | disclosed |
| WO-2004110368-A2 | COMBINATION THERAPY FOR THE TREATMENT OF HYPERTENSION | MERCK & CO., INC. (US) | 2004-12-23 | — | — | WO | disclosed |
| US-5410052-A | Useful for extraction of ligand such as molecular oxygen from fluid environment and for release of such ligand | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-04-25 | — | — | US | disclosed |
| US-4959135-A | OXYGEN | AQUANAUTICS CORPORATION (US) | 1990-09-25 | — | — | US | disclosed |
| WO-1988006641-A1 | POLYALKYLAMINE COMPLEXES FOR LIGAND EXTRACTION AND GENERATION | AQUANAUTICS CORPORATION (US) | 1988-09-07 | — | — | WO | disclosed |