Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 3/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4041670 | 0.96 | MTOR (0.41) | MTORADKNISCHSCN2ANPY5R | |
| SCHEMBL4046324 | 0.86 | KMO (0.40) | NISCHALDH1A1NPC1CYP1A2CYP3A4 | |
| SCHEMBL4043823 | 0.82 | MKNK1 (0.41) | NPY5RCYP1A2CYP3A4IDO1 | |
| SCHEMBL4046862 | 0.79 | MEN1 (0.55) | NPY5RALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL4044973 | 0.79 | ASIC3 (0.45) | MTORADKNISCHNPY5RCYP1A2 | |
| SCHEMBL2652005 | 0.78 | SMN1; SMN2 (0.38) | ALDH1A1NPC1RAB9AKDM4EGAA | |
| SCHEMBL17626003 | 0.78 | KDM4E (0.41) | SCN2ANPY5RDCUN1D1NR1H2NR1H3 | |
| SCHEMBL4047558 | 0.78 | DGAT1 (0.37) | NR1H2NR1H3ALDH1A1NPC1RAB9A | |
| SCHEMBL4049587 | 0.78 | ALDH1A1 (0.41) | MTORALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL4050439 | 0.77 | CYP11B2 (0.42) | SCN2ANPY5RRAB9AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 141 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | BIOTHERYX, INC. | 2023-10-26 | — | — | US | claimed |
| CN-107949380-B | Benzenesulfonamide up-regulator of NPC1 for niemann-pick disease and other lysosomal storage diseases | 西奈山伊坎医学院 | 2021-07-06 | — | — | CN | claimed |
| US-10239830-B2 | Benzenesulfonamide upregulators of NPC1 for Neimann-Pick disease and other lysosomal storage disorders | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2019-03-26 | — | — | US | claimed |
| US-20180044286-A1 | BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2018-02-15 | — | — | US | claimed |
| EP-3256116-A1 | BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS | Icahn School of Medicine at Mount Sinai (US) | 2017-12-20 | — | — | EP | claimed |
| WO-2016130774-A1 | BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2016-08-18 | — | — | WO | claimed |
| EP-1441719-B1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-03-30 | — | — | EP | claimed |
| US-7803819-B2 | DPP IV inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2010-09-28 | — | — | US | claimed |
| US-20070259925-A1 | DPP IV INHIBITORS | BOEHRINGER MARKUS | 2007-11-08 | — | — | US | claimed |
| US-20050096348-A1 | DPP IV inhibitors | BOEHRINGER MARKUS (CH) | 2005-05-05 | — | — | US | claimed |
| US-6861440-B2 | DPP IV inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-03-01 | — | — | US | claimed |
| EP-1441719-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-08-04 | — | — | EP | claimed |
| US-20030130281-A1 | DPP IV inhibitors | HOFFMAN-LA ROCHE INC. | 2003-07-10 | — | — | US | claimed |
| WO-2003037327-A1 | N-SUBSTITUTED PYRROLIDIN DERIVATIVES AS DIPEPTIDYL PEPTIDASE IV INHIBITORS | F. HOFFMANN-LA-ROCHE AG (CH) | 2003-05-08 | — | — | WO | claimed |
| US-6534503-B1 | Treating sexual dysfunction, such as erectile dysfunction or sexual arousal disorder, with a compound having the generic formula X1-X2-(D)Phe-Arg-(D)Trp-X3. A particularly useful compound is HP-228, which has the formula | LION BIOSCIENCE AG (DE) | 2003-03-18 | — | — | US | claimed |
| EP-1214330-A1 | BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION Bioscience AG (DE) | 2002-06-19 | — | — | EP | claimed |
| WO-2001021634-A1 | BENZIMIDAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF | LION BIOSCIENCE AG (DE) | 2001-03-29 | — | — | WO | claimed |
| CN-1265033-A | Certain diarylimidaozle derivatives, new class of NPY speific ligands | NEUROGEN CORP (US) | 2000-08-30 | — | — | CN | claimed |
| CN-115335445-B | Tackifier composition | 花王株式会社 | 2024-05-03 | — | — | CN | disclosed |
| EP-0240015-A2 | Carbostyril derivatives, process for preparing them, pharmaceutical composition, and use | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1987-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230339904-A1 | ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS | CSNK1A1, CSNK1D, CSNK1G1 | MTOR 2454/4885ADK 1072/4885NISCH 2463/4885 |
| US-10239830-B2 | Benzenesulfonamide upregulators of NPC1 for Neimann-Pick disease and other lysosomal storage disorders | GBA1, NPC1, NPC1L1 | MTOR 2261/4885ADK 4279/4885NISCH 229/4885 |
| US-20180044286-A1 | BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS | GBA1, NPC1, NPC1L1 | MTOR 2261/4885ADK 4279/4885NISCH 229/4885 |
| US-20070259925-A1 | DPP IV INHIBITORS | DPP4, DPP3, DPP7 | MTOR 3036/4885ADK 1309/4885NISCH 2644/4885 |
| US-20030130281-A1 | DPP IV inhibitors | DPP4, DPP3, DPP7 | MTOR 3245/4885ADK 1208/4885NISCH 3631/4885 |
| US-20050096348-A1 | DPP IV inhibitors | DPP4, DPP3, DPP7 | MTOR 3036/4885ADK 1309/4885NISCH 2644/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.