Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ESRRG | P62508 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653418 | 0.86 | GCGR (0.41) | ADRB2ADRB1MAPTSMN1; SMN2CA12 | |
| SCHEMBL2653577 | 0.85 | GCGR (0.51) | MAPTCA1CA2POLBRAB9A | |
| SCHEMBL2655056 | 0.84 | GCGR (0.47) | MAPTMEN1KMT2A | |
| SCHEMBL2655622 | 0.83 | ALDH1A1 (0.45) | ADRB2ADRB1MAPTALDH1A1HPGD | |
| SCHEMBL2655457 | 0.83 | NPC1 (0.44) | MAPTSMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL2655101 | 0.82 | ESRRG (0.49) | ADRB2ADRB1CA12CA1CA2 | |
| SCHEMBL2654035 | 0.82 | HPGD (0.38) | ADRB2ADRB1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL2654759 | 0.81 | GCG (0.40) | MAPTSMN1; SMN2ALDH1A1LMNARAB9A | |
| SCHEMBL2657119 | 0.80 | NR1H4 (0.47) | ADRB2ADRB1CA12CA1CA2 | |
| SCHEMBL2662283 | 0.79 | MEN1 (0.46) | ADRB2ADRB1CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |