Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRG | P62508 | 6/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 5/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.49 |
| ▸ | ESRRB | O95718 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2657119 | 0.97 | NR1H4 (0.47) | ESRRGNR1H4EPHX2ESRRBL3MBTL1 | |
| SCHEMBL2654353 | 0.91 | NR1H4 (0.54) | ESRRGNR1H4EPHX2ESRRBL3MBTL1 | |
| SCHEMBL2662283 | 0.88 | MEN1 (0.46) | MEN1KMT2AADRB2ADRB1CA1 | |
| SCHEMBL2653577 | 0.88 | GCGR (0.51) | ESRRGNR1H4EPHX2ESRRBL3MBTL1 | |
| SCHEMBL2655270 | 0.88 | GCGR (0.53) | ESRRGNR1H4EPHX2ESRRBL3MBTL1 | |
| SCHEMBL2657309 | 0.87 | ESRRG (0.53) | ESRRGNR1H4EPHX2ESRRBL3MBTL1 | |
| SCHEMBL2653943 | 0.87 | NR1H4 (0.48) | ESRRGNR1H4EPHX2ESRRBL3MBTL1 | |
| SCHEMBL2653571 | 0.82 | ADRB2 (0.41) | ESRRGNPC1RAB9AMEN1KMT2A | |
| SCHEMBL2653054 | 0.82 | CA12 (0.42) | MEN1KMT2AADRB2ADRB1CA1 | |
| SCHEMBL2655436 | 0.81 | NPC1 (0.55) | ESRRGNR1H4EPHX2ESRRBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |