Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 5/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655007 | 0.94 | PPARG (0.56) | PPARGCYP1A2CYP2C19SMN1; SMN2ALDH1A1 | |
| SCHEMBL14763612 | 0.86 | KDM4E (0.50) | ALDH1A1CA2TSHRLMNAHSD17B10 | |
| SCHEMBL9030811 | 0.85 | LMNA (0.50) | ALDH1A1CA2TSHRLMNAHSD17B10 | |
| SCHEMBL30768207 | 0.85 | CYP1A2 (0.47) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL6472205 | 0.82 | CYP1A2 (0.45) | CYP1A2CYP2C19SMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL23521275 | 0.82 | KMT2A (0.50) | PPARGALDH1A1CYP3A4CA2TSHR | |
| SCHEMBL29360777 | 0.82 | KMT2A (0.50) | PPARGALDH1A1CYP3A4CA2TSHR | |
| SCHEMBL29869129 | 0.82 | KMT2A (0.50) | PPARGALDH1A1CYP3A4CA2TSHR | |
| SCHEMBL23521291 | 0.82 | KMT2A (0.50) | PPARGALDH1A1CYP3A4CA2TSHR | |
| SCHEMBL1935639 | 0.82 | KMT2A (0.50) | PPARGALDH1A1CYP3A4CA2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |