Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.51 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.51 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2653618 | 0.94 | PPARG (0.49) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL28532492 | 0.86 | PRSS1 (0.52) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL29139948 | 0.86 | PRSS1 (0.52) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL29139944 | 0.85 | ALDH1A1 (0.50) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL6436956 | 0.85 | ALDH1A1 (0.50) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL29148911 | 0.84 | PRSS1 (0.50) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL30768203 | 0.84 | PRSS1 (0.47) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL7200254 | 0.83 | ALDH1A1 (0.49) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL6436469 | 0.83 | ALDH1A1 (0.49) | PPARGPRSS1PRSS2PRSS3ALDH1A1 | |
| SCHEMBL7643422 | 0.83 | ALDH1A1 (0.49) | PPARGPRSS1PRSS2PRSS3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |