Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26544376 | 0.80 | SMN1; SMN2 (0.38) | TP53ALDH1A1GAASMN1; SMN2HTT | |
| SCHEMBL29939188 | 0.80 | SMN1; SMN2 (0.38) | TP53ALDH1A1GAASMN1; SMN2HTT | |
| SCHEMBL14417074 | 0.76 | TP53 (0.50) | TP53ALDH1A1GAASMN1; SMN2HTT | |
| SCHEMBL2772351 | 0.76 | CYP19A1 (0.43) | TP53POLBL3MBTL1CYP19A1CYP2D6 | |
| SCHEMBL22068089 | 0.75 | GAA (0.40) | TP53ALDH1A1GAASMN1; SMN2POLB | |
| SCHEMBL22068553 | 0.74 | TP53 (0.47) | TP53ALDH1A1GAASMN1; SMN2POLB | |
| SCHEMBL16688562 | 0.74 | TP53 (0.47) | TP53ALDH1A1GAASMN1; SMN2POLB | |
| SCHEMBL31380064 | 0.73 | MAPT (0.53) | ALDH1A1SMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL31380063 | 0.73 | MAPT (0.53) | ALDH1A1SMN1; SMN2POLBNPC1RAB9A | |
| SCHEMBL24960898 | 0.73 | SMN1; SMN2 (0.45) | TP53ALDH1A1GAASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | NOVARTIS AG (CH) | 2023-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11787785-B2 | Pyrazolopyridine derivatives and uses thereof | HBZ, ZFX, WIZ | TP53 1001/4885ALDH1A1 1243/4885GAA 1170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.