Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1565103 | 0.85 | LMNA (0.48) | LMNAHSPA5PTGESALOX5PPARG | |
| SCHEMBL2654200 | 0.81 | NPC1 (0.43) | LMNAHSPA5NPC1RAB9APKM | |
| SCHEMBL1565298 | 0.78 | NPC1 (0.56) | LMNAHSPA5NPC1RAB9APKM | |
| SCHEMBL2653915 | 0.77 | SMN1; SMN2 (0.39) | LMNAHSPA5PPARGNPC1RAB9A | |
| SCHEMBL1565568 | 0.77 | NPC1 (0.55) | LMNAHSPA5NPC1RAB9APKM | |
| SCHEMBL2652000 | 0.76 | HSPA5 (0.36) | LMNAHSPA5NPC1RAB9AFFAR2 | |
| SCHEMBL2655334 | 0.76 | FFAR2 (0.42) | LMNAHSPA5PPARGNPC1RAB9A | |
| SCHEMBL2655304 | 0.75 | CYP1A2 (0.39) | LMNAHSPA5NPC1RAB9APKM | |
| SCHEMBL1565765 | 0.75 | LMNA (0.53) | LMNAHSPA5NPC1RAB9APKM | |
| SCHEMBL1565548 | 0.72 | HSPA5 (0.49) | LMNAHSPA5NPC1RAB9APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | claimed |