Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1565038 | 0.83 | RAB9A (0.54) | SMN1; SMN2MAPK1LMNARAB9ANPC1 | |
| SCHEMBL2652000 | 0.82 | HSPA5 (0.36) | SMN1; SMN2LMNARAB9ANPC1HSPA5 | |
| SCHEMBL2654200 | 0.82 | NPC1 (0.43) | SMN1; SMN2LMNARAB9ANPC1HSPA5 | |
| SCHEMBL1565416 | 0.81 | HSPA5 (0.50) | SMN1; SMN2MAPK1LMNARAB9ANPC1 | |
| SCHEMBL2655334 | 0.78 | FFAR2 (0.42) | SMN1; SMN2MAPK1LMNARAB9ANPC1 | |
| SCHEMBL2653858 | 0.77 | LMNA (0.37) | SMN1; SMN2LMNARAB9ANPC1HSPA5 | |
| SCHEMBL2655304 | 0.76 | CYP1A2 (0.39) | SMN1; SMN2LMNARAB9ANPC1HSPA5 | |
| SCHEMBL1565655 | 0.75 | HSPA5 (0.52) | SMN1; SMN2LMNARAB9ANPC1HSPA5 | |
| SCHEMBL1565298 | 0.74 | NPC1 (0.56) | SMN1; SMN2LMNARAB9ANPC1HSPA5 | |
| SCHEMBL1565568 | 0.73 | NPC1 (0.55) | SMN1; SMN2LMNARAB9ANPC1HSPA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458382-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2004-09-22 | — | — | EP | claimed |
| WO-2003055482-A1 | AMIDE DERIVATIVES AS GK ACTIVATORS | NOVO NORDISK A/S (DK) | 2003-07-10 | — | — | WO | claimed |