Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GCGR | P47871 | 2/20 | 0.47 |
| ▸ | GIPR | P48546 | 1/20 | 0.47 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GCG | P01275 | 2/20 | 0.46 |
| ▸ | PDE4A | P27815 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2656779 | 0.90 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2662580 | 0.85 | S1PR1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2655041 | 0.81 | PPARD (0.50) | GCGRGCGPPARGPPARDPPARA | |
| SCHEMBL2653225 | 0.79 | MEN1 (0.46) | GCGRGIPRS1PR1PPARDPPARA | |
| SCHEMBL2654437 | 0.78 | S1PR1 (0.55) | GAAS1PR1MAPTHTTCYP2D6 | |
| SCHEMBL2653847 | 0.77 | NPC1 (0.57) | GCGRS1PR1MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL2654574 | 0.77 | GCG (0.57) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL2655491 | 0.77 | S1PR1 (0.51) | GCGRS1PR1MAPTSMN1; SMN2NPC1 | |
| SCHEMBL11471260 | 0.77 | NPC1 (0.66) | MCHR1GAAMAPTCYP2D6CHRM1 | |
| SCHEMBL11473837 | 0.77 | NPC1 (0.66) | MCHR1GAAMAPTCYP2D6CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |