Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 10/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660935 | 0.84 | EGFR (0.76) | EGFRSRCNPC1RAB9AALDH1A1 | |
| SCHEMBL8998908 | 0.73 | SRC (1.00) | EGFRSRCNPC1RAB9AALDH1A1 | |
| SCHEMBL25720375 | 0.70 | RAB9A (1.00) | EGFRSRCNPC1RAB9AALDH1A1 | |
| SCHEMBL24054913 | 0.70 | MEN1 (0.73) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL27488058 | 0.69 | L3MBTL1 (0.64) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL2661003 | 0.69 | NPC1 (0.83) | EGFRSRCNPC1RAB9AALDH1A1 | |
| SCHEMBL10675667 | 0.68 | RAB9A (0.67) | EGFRSRCNPC1RAB9AALDH1A1 | |
| SCHEMBL2642750 | 0.68 | KCNMA1 (0.56) | NPC1RAB9AALDH1A1TP53KDM4E | |
| SCHEMBL9384187 | 0.68 | NPC1 (0.72) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL3001993 | 0.68 | KMT2A (0.51) | EGFRSRCNPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549638-A1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| WO-2004031179-A1 | INDOLE-3-CARBOXAMIDES AS GLUCOKINASE (GK) ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2004-04-15 | — | — | WO | disclosed |