Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480009 | 0.74 | GAA (0.34) | ALDH1A1GAAKMT2ACYP2D6CYP2C19 | |
| SCHEMBL4483446 | 0.68 | PSEN1 (0.37) | ALDH1A1GAAKMT2ACYP2D6CYP2C19 | |
| SCHEMBL2653003 | 0.66 | SMN1; SMN2 (0.54) | ALDH1A1GAAKMT2ACYP2D6CYP2C19 | |
| SCHEMBL2653396 | 0.64 | LMNA (0.39) | ALDH1A1GAAKMT2AMEN1CYP3A4 | |
| SCHEMBL2653581 | 0.57 | MEN1 (0.48) | ALDH1A1KMT2ACYP2D6CYP2C19MEN1 | |
| SCHEMBL3363467 | 0.54 | ALDH1A1 (0.55) | ALDH1A1CYP2C19CYP1A2CYP3A4TSHR | |
| SCHEMBL1164041 | 0.54 | SMN1; SMN2 (0.58) | ALDH1A1GAAKMT2ACYP2C19MEN1 | |
| SCHEMBL2654986 | 0.54 | CA1 (0.41) | — | |
| SCHEMBL2652662 | 0.54 | CYP4F2 (0.43) | ALDH1A1KMT2AMEN1RECQLHPGD | |
| SCHEMBL6994378 | 0.54 | KMT2A (0.56) | ALDH1A1GAAKMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585739-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2005-10-19 | — | — | EP | disclosed |
| WO-2004063179-A1 | SUBSTITUTED ARYLCYCLOPROPYLACETAMIDES AS GLUCOKINASE ACTIVATORS | ELI LILLY AND COMPANY (US) | 2004-07-29 | — | — | WO | disclosed |