Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTC4S | Q16873 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GCK | P35557 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | GALR3 | O60755 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2648137 | 0.96 | LTC4S (0.52) | LTC4SSMN1; SMN2ALDH1A1TDP1GCK | |
| SCHEMBL2647572 | 0.89 | GCK (0.46) | LTC4SSMN1; SMN2GCKTP53NPC1 | |
| SCHEMBL6596927 | 0.88 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1TDP1GCKLMNA | |
| SCHEMBL2648107 | 0.86 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1TDP1GCKLMNA | |
| SCHEMBL2647650 | 0.84 | GCK (0.48) | GCK | |
| SCHEMBL2647253 | 0.83 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1TDP1GCKLMNA | |
| SCHEMBL2648600 | 0.83 | GCK (0.47) | GCK | |
| SCHEMBL2647614 | 0.82 | GCK (0.49) | GCK | |
| SCHEMBL2646210 | 0.81 | MAPT (0.59) | SMN1; SMN2ALDH1A1TDP1GCKLMNA | |
| SCHEMBL2656498 | 0.80 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1TDP1GCKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1282611-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-02-12 | — | — | EP | disclosed |
| WO-2001085706-A1 | SUBSTITUTED PHENYLACETAMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-11-15 | — | — | WO | disclosed |