Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PPARD | Q03181 | 4/20 | 0.34 |
| ▸ | GCG | P01275 | 4/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | GLP1R | P43220 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 3/20 | 0.33 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654750 | 0.93 | GCGR (0.38) | GCGRHPGDMAPTEPHX2PPARD | |
| SCHEMBL2653083 | 0.88 | HPGD (0.41) | GCGRHPGDMAPTEPHX2PPARD | |
| SCHEMBL2654872 | 0.88 | GCGR (0.42) | GCGRHPGDMAPTEPHX2PPARD | |
| SCHEMBL2652772 | 0.88 | HPGD (0.42) | GCGRHPGDMAPTEPHX2PPARD | |
| SCHEMBL2653931 | 0.88 | HPGD (0.39) | GCGRHPGDMAPTEPHX2PPARD | |
| SCHEMBL2654086 | 0.87 | GCGR (0.40) | GCGRHPGDMAPTEPHX2PPARD | |
| SCHEMBL2655507 | 0.87 | GCGR (0.45) | GCGRPPARDGCGCHRM5GLP1R | |
| SCHEMBL2654978 | 0.85 | MAPT (0.39) | GCGRHPGDMAPTEPHX2PPARD | |
| SCHEMBL2653672 | 0.84 | GCGR (0.39) | GCGRMAPTEPHX2PPARDPPARA | |
| SCHEMBL2666428 | 0.83 | GCGR (0.40) | GCGRMAPTEPHX2PPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |