Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GCG | P01275 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 3/20 | 0.34 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | GLP1R | P43220 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654748 | 0.93 | GCGR (0.37) | GCGRMAPTGCGHPGDPPARD | |
| SCHEMBL2655507 | 0.93 | GCGR (0.45) | GCGRGCGPPARDPPARAPPARG | |
| SCHEMBL2653931 | 0.88 | HPGD (0.39) | GCGRMAPTHPGDPPARDPPARA | |
| SCHEMBL2654086 | 0.88 | GCGR (0.40) | GCGRMAPTHPGDPPARDPPARA | |
| SCHEMBL2653083 | 0.88 | HPGD (0.41) | GCGRMAPTHPGDPPARDPPARA | |
| SCHEMBL2652772 | 0.87 | HPGD (0.42) | GCGRMAPTHPGDPPARDPPARA | |
| SCHEMBL2654978 | 0.86 | MAPT (0.39) | GCGRMAPTHPGDPPARDPPARA | |
| SCHEMBL2666428 | 0.86 | GCGR (0.40) | GCGRMAPTPPARDPPARAPPARG | |
| SCHEMBL2653672 | 0.84 | GCGR (0.39) | GCGRMAPTPPARDPPARAPPARG | |
| SCHEMBL2654872 | 0.84 | GCGR (0.42) | GCGRMAPTHPGDPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856090-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006086488-A2 | SUBSTITUTED THIOPHENE DERIVATIVES AS GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2006-08-17 | — | — | WO | disclosed |