Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26548259 | 0.81 | ALDH1A1 (0.42) | ALDH1A1LMNASMN1; SMN2HTT | |
| SCHEMBL26134405 | 0.78 | TDP1 (0.50) | TDP1SIRT2SIRT1ALDH1A1LMNA | |
| SCHEMBL26100484 | 0.77 | TDP1 (0.48) | TDP1KCNJ1KCNH2HRH3SIRT2 | |
| SCHEMBL26548350 | 0.77 | HRH3 (0.46) | KCNJ1KCNH2HRH3KDM4EALDH1A1 | |
| SCHEMBL23728268 | 0.77 | KDM4E (0.48) | KCNJ1KCNH2HRH3POLBKDM4E | |
| SCHEMBL26548346 | 0.76 | POLB (0.47) | TDP1KCNJ1KCNH2HRH3POLB | |
| SCHEMBL30361402 | 0.76 | KCNJ1 (0.61) | KCNJ1KCNH2HRH3KDM4EALDH1A1 | |
| SCHEMBL23747401 | 0.74 | HRH3 (0.48) | KCNJ1KCNH2HRH3KDM4EALDH1A1 | |
| SCHEMBL9456724 | 0.72 | TDP1 (0.54) | TDP1KCNJ1SIRT2SIRT1POLB | |
| SCHEMBL26100782 | 0.72 | HRH3 (0.52) | KCNJ1HRH3KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
| US-20230133132-A1 | NAMPT MODULATORS | CYTOKINETICS, INC. | 2023-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230133132-A1 | NAMPT MODULATORS | NAMPT, MC4R, SIRT1 | TDP1 4486/4885KCNJ1 2939/4885KCNH2 3282/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.