Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 3/20 | 0.34 |
| ▸ | FABP4 | P15090 | 5/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 5/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2961980 | 0.79 | MTNR1A (0.43) | PDE10AMTNR1AMTNR1BPOLBCASP3 | |
| SCHEMBL12299867 | 0.71 | HCRTR1 (0.43) | PDE10APOLBCASP3SENP7SENP6 | |
| SCHEMBL18997875 | 0.70 | POLB (0.44) | PDE10AMTNR1AMTNR1BPOLBCASP3 | |
| SCHEMBL11510529 | 0.70 | TRPM8 (0.42) | TRPM8 | |
| SCHEMBL13827635 | 0.69 | POLB (0.40) | MTNR1AMTNR1BPOLBCASP3SENP7 | |
| SCHEMBL21092169 | 0.69 | IDH1 (0.43) | PDE10AMTNR1AMTNR1BPOLBCASP3 | |
| SCHEMBL469197 | 0.69 | POLB (0.40) | MTNR1AMTNR1BPOLBCASP3SENP7 | |
| SCHEMBL23734140 | 0.68 | TRPM8 (0.36) | KDM4EALDH1A1TRPM8 | |
| SCHEMBL12259534 | 0.68 | FABP4 (0.34) | PDE10APOLBCASP3SENP7SENP6 | |
| SCHEMBL15479711 | 0.68 | POLB (0.40) | POLBCASP3SENP7SENP6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023196975-A1 | COMPOUNDS THAT INTERACT WITH RAS SUPERFAMILY PROTEINS FOR TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, LLC (US) | 2023-10-12 | — | — | WO | disclosed |