Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 7/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CCR3 | P51677 | 3/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765961 | 0.88 | NTRK1 (0.46) | NTRK1MCHR1SIGMAR1SMOL3MBTL1 | |
| SCHEMBL21765957 | 0.85 | NTRK1 (0.40) | CACNA1HNTRK1IRAK4 | |
| SCHEMBL21765942 | 0.85 | CACNA1G (0.44) | CACNA1GCACNA1HCACNA1INTRK1IRAK4 | |
| SCHEMBL26549291 | 0.82 | NTRK1 (0.44) | CACNA1GCACNA1HCACNA1INTRK1MCHR1 | |
| SCHEMBL30057558 | 0.81 | MCHR1 (0.48) | MCHR1SIGMAR1L3MBTL1CCR3PRKAA2 | |
| SCHEMBL21765958 | 0.81 | NTRK1 (0.43) | NTRK1 | |
| SCHEMBL26135997 | 0.81 | NTRK1 (0.43) | NTRK1 | |
| SCHEMBL30032192 | 0.80 | NTRK1 (0.37) | NTRK1MCHR1CCR3 | |
| SCHEMBL30033137 | 0.80 | NTRK1 (0.37) | NTRK1MCHR1CCR3 | |
| SCHEMBL21752901 | 0.80 | NTRK1 (0.37) | NTRK1MCHR1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |