Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 6/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 3/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765961 | 0.94 | NTRK1 (0.46) | NTRK1IRAK4SIGMAR1MCHR1SMO | |
| SCHEMBL21765934 | 0.85 | NTRK1 (0.46) | NTRK1IRAK4AOC3CACNA1GCACNA1H | |
| SCHEMBL26549318 | 0.82 | CACNA1G (0.42) | NTRK1IRAK4SIGMAR1MCHR1CACNA1G | |
| SCHEMBL30057602 | 0.80 | HSD11B1 (0.46) | NTRK1SIGMAR1MCHR1TGFBR1ROCK2 | |
| SCHEMBL21637236 | 0.80 | IRAK4 (0.48) | NTRK1IRAK4TGFBR1 | |
| SCHEMBL21765957 | 0.78 | NTRK1 (0.40) | NTRK1IRAK4CACNA1HTGFBR1 | |
| SCHEMBL25457169 | 0.78 | NTRK1 (0.41) | NTRK1 | |
| SCHEMBL30033218 | 0.78 | NTRK1 (0.41) | NTRK1 | |
| SCHEMBL30032435 | 0.78 | NTRK1 (0.41) | NTRK1 | |
| SCHEMBL21752928 | 0.78 | NTRK1 (0.41) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |