Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 9/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26549318 | 0.85 | CACNA1G (0.42) | NTRK1IRAK4CACNA1H | |
| SCHEMBL30032447 | 0.82 | HSD11B1 (0.43) | NTRK1 | |
| SCHEMBL30032432 | 0.81 | NTRK1 (0.52) | NTRK1 | |
| SCHEMBL21752890 | 0.81 | NTRK1 (0.52) | NTRK1 | |
| SCHEMBL23673856 | 0.81 | NTRK1 (0.52) | NTRK1 | |
| SCHEMBL26549291 | 0.78 | NTRK1 (0.44) | NTRK1IRAK4CACNA1HTGFBR1 | |
| SCHEMBL21752807 | 0.78 | NTRK1 (0.41) | NTRK1 | |
| SCHEMBL21752878 | 0.78 | NTRK1 (0.41) | NTRK1 | |
| SCHEMBL25457167 | 0.78 | NTRK1 (0.41) | NTRK1 | |
| SCHEMBL30032909 | 0.78 | NTRK1 (0.41) | NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840832-B1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LTD (GB) | 2023-10-11 | — | — | EP | disclosed |
| WO-2020039209-A1 | IMIDAZO[1,2-B]PYRIDAZINES AS TRK INHIBITORS | BENEVOLENTAI BIO LIMITED (GB) | 2020-02-27 | — | — | WO | disclosed |