Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | SCN1A | P35498 | 1/20 | 0.57 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | GHSR | Q92847 | 1/20 | 0.57 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.57 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | NR2E1 | Q9Y466 | 4/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2655547 | 0.85 | ALDH1A1 (0.52) | ALDH1A1KDM4EHPGDLMNAGAA | |
| SCHEMBL2654506 | 0.82 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDLMNAHTT | |
| SCHEMBL6250517 | 0.79 | KDM4E (0.65) | ALDH1A1KDM4EHPGDABCB11LMNA | |
| SCHEMBL31673005 | 0.79 | KDM4E (0.65) | ALDH1A1KDM4EHPGDABCB11LMNA | |
| SCHEMBL4678263 | 0.79 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDLMNAGAA | |
| SCHEMBL31729873 | 0.76 | NR2E1 (0.67) | ALDH1A1KDM4EHPGDABCB11LMNA | |
| SCHEMBL9198147 | 0.76 | HTR3E (0.61) | ALDH1A1KDM4EHPGDABCB11LMNA | |
| SCHEMBL4677599 | 0.76 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDLMNASMN1; SMN2 | |
| SCHEMBL9198080 | 0.75 | HTR3E (0.61) | ALDH1A1KDM4EHPGDABCB11LMNA | |
| SCHEMBL28378761 | 0.75 | KDM4E (0.62) | ALDH1A1KDM4EHPGDABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583532-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | Astrazeneca AB (SE) | 2005-10-12 | — | — | EP | claimed |
| WO-2004045614-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | WO | claimed |
| EP-1583532-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | Astrazeneca AB (SE) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004045614-A1 | QUINOLINE DERIVATIVES AS GLUCOKINASE LIGANDS | ASTRAZENECA AB (SE) | 2004-06-03 | — | — | WO | disclosed |