Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.37 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2654945 | 0.89 | RXRA (0.38) | CYP4A11RAB9ACYP4F2NPC1SMN1; SMN2 | |
| SCHEMBL2655814 | 0.85 | MEN1 (0.42) | RAB9AGAANPC1ALDH1A1MAPT | |
| SCHEMBL2655045 | 0.82 | CCR6 (0.44) | CYP4A11RAB9AGAACYP4F2NPC1 | |
| SCHEMBL2654694 | 0.76 | CYP4A11 (0.47) | CYP4A11RAB9AGAACYP4F2NPC1 | |
| SCHEMBL2655395 | 0.76 | GCGR (0.41) | CYP4A11MAPTLMNASMN1; SMN2TP53 | |
| SCHEMBL1765675 | 0.72 | MAPT (0.37) | RAB9AGAAALDH1A1MAPTLMNA | |
| SCHEMBL2652782 | 0.71 | CYP4A11 (0.61) | CYP4A11GAACYP4F2NPC1ALDH1A1 | |
| SCHEMBL336046 | 0.69 | ATM (0.51) | GAAALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL30331909 | 0.69 | ATM (0.51) | GAAALDH1A1MAPTLMNAL3MBTL1 | |
| SCHEMBL19002551 | 0.69 | CYP4A11 (0.62) | CYP4A11GAACYP4F2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758853-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123668-A1 | GLUCAGON RECEPTOR ANTAGONISTS, PREPARATION AND THERAPEUTIC USES | ELI LILLY AND COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |