Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 5/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | FFAR2 | O15552 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2667092 | 0.81 | GCK (0.63) | GCKALOX15FFAR2LMNATSHR | |
| SCHEMBL1107000 | 0.75 | ADORA2A (0.68) | FFAR2LMNATSHRHSPA9MEN1 | |
| SCHEMBL2654208 | 0.74 | GCK (0.47) | GCKFFAR2LMNASMN1; SMN2HSPA9 | |
| SCHEMBL2661212 | 0.74 | GCK (0.48) | GCKFFAR2LMNASMN1; SMN2HSPA9 | |
| SCHEMBL2651674 | 0.73 | LMNA (0.46) | GCKFFAR2LMNAHSPA9MEN1 | |
| SCHEMBL2661654 | 0.73 | GCK (0.48) | GCKFFAR2LMNASMN1; SMN2HSPA9 | |
| SCHEMBL2662039 | 0.73 | LMNA (0.45) | GCKLMNASMN1; SMN2HSPA9MEN1 | |
| SCHEMBL27891187 | 0.72 | FFAR2 (0.62) | FFAR2LMNASMN1; SMN2TSHRHSPA9 | |
| SCHEMBL2652650 | 0.71 | LMNA (0.52) | GCKLMNASMN1; SMN2TSHRMEN1 | |
| SCHEMBL7868161 | 0.71 | MEN1 (0.62) | GCKFFAR2SMN1; SMN2TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001875-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2008-12-17 | — | — | EP | claimed |
| WO-2007104034-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-09-13 | — | — | WO | claimed |
| EP-2001875-A2 | GLUCOKINASE ACTIVATORS | Takeda San Diego, Inc. (US) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007104034-A2 | GLUCOKINASE ACTIVATORS | TAKEDA SAN DIEGO, INC. (US) | 2007-09-13 | — | — | WO | disclosed |