Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PRNP | P04156 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25652546 | 0.89 | L3MBTL1 (0.48) | L3MBTL1PRNPMAPTRXFP1LTB4R | |
| SCHEMBL25652551 | 0.87 | L3MBTL1 (0.46) | L3MBTL1PRNPMAPTRXFP1LTB4R | |
| SCHEMBL14570639 | 0.84 | PRNP (0.57) | L3MBTL1PRNPMAPTRXFP1LTB4R | |
| SCHEMBL6171945 | 0.84 | MAPT (0.50) | L3MBTL1PRNPMAPTCYP1A2CYP2D6 | |
| SCHEMBL26565172 | 0.84 | L3MBTL1 (0.49) | L3MBTL1PRNPMAPTRXFP1ALDH1A1 | |
| SCHEMBL25259300 | 0.83 | L3MBTL1 (0.41) | L3MBTL1PRNPMAPTLTB4RSMN1; SMN2 | |
| SCHEMBL31059229 | 0.83 | L3MBTL1 (0.41) | L3MBTL1PRNPMAPTLTB4RSMN1; SMN2 | |
| SCHEMBL6170480 | 0.83 | LTB4R (0.45) | L3MBTL1PRNPMAPTLTB4RSMN1; SMN2 | |
| SCHEMBL25269537 | 0.82 | L3MBTL1 (0.40) | L3MBTL1PRNPMAPTLTB4RALDH1A1 | |
| SCHEMBL31059237 | 0.82 | L3MBTL1 (0.40) | L3MBTL1PRNPMAPTLTB4RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018011-B2 | Macrocyclic compounds and compositions, and methods of preparing and using the same | KURA ONCOLOGY, INC. (US) | 2024-06-25 | — | — | US | disclosed |
| US-20230322711-A1 | MACROCYCLIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF PREPARING AND USING THE SAME | WUXI APPTEC (HONG KONG) LIMITED (CN) | 2023-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12018011-B2 | Macrocyclic compounds and compositions, and methods of preparing and using the same | FNTA, FDPS, GGPS1 | L3MBTL1 4194/4885PRNP 4290/4885MAPT 4146/4885 |
| US-20230322711-A1 | MACROCYCLIC COMPOUNDS AND COMPOSITIONS, AND METHODS OF PREPARING AND USING THE SAME | FNTA, FDPS, GGPS1 | L3MBTL1 4194/4885PRNP 4290/4885MAPT 4146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.